1882. North of Edinburgh, on the edge of an isolated loch, lies an institution of crumbling stone, where a strange doctor collects orphans with unusual abilities. In London, two children with such powers are hunted by a figure of darkness – a man made of smoke. Charlie Ovid discovers a gift for healing himself through a brutal upbringing in Mississippi, while Marlowe, a foundling from a railway freight, glows with a strange bluish light. When two grizzled detectives are recruited to escort them north to safety, they are confronted by a sinister, dangerous force that threatens to upend the world as they know it. What follows is a journey from the gaslit streets of London to the lochs of Scotland, where other gifted children – the Talents – have been gathered at Cairndale Institute, and the realms of the dead and the living collide.